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Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. From 25 August 2021 onwards, the OPN moved to a fortnightly period with a sample size of around 5,000 households in each period. Like the OPN prior and during the coronavirus pandemic, the OPN continues to be primarily collected through a self-completion online questionnaire. However, some responses (around 1% on average) have been collected with the help of telephone interviewers, for example when respondents indicate they are unable to complete the online survey themselves. He, K.M.; Sun, J.; Tang, X.O. Guided image filtering. IEEE Trans. Pattern Anal. Mach. Intell. 2013, 35, 1397–1409. [ Google Scholar] [ CrossRef]

Hepatocyte growth factor ( HGF) or scatter factor ( SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing. [5] Function [ edit ] HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast. [18] [19] [20] Plasma from patients with advanced heart failure presents increased levels of HGF, which correlates with a negative prognosis and a high risk of mortality. [22] [23] Circulating HGF has been also identified as a prognostic marker of severity in patients with hypertension. [24] Circulating HGF has been also suggested as a precocious biomarker for the acute phase of bowel inflammation. [25] Pharmacokinetics [ edit ] Wright JW, Harding JW (2015). "The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease". Journal of Alzheimer's Disease. 45 (4): 985–1000. doi: 10.3233/JAD-142814. PMID 25649658.

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Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK (October 1991). "Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor". The EMBO Journal. 10 (10): 2867–78. doi: 10.1002/j.1460-2075.1991.tb07836.x. PMC 452997. PMID 1655405. Jobson, D.J.; Rahman, Z.; Wooden, G.A. Retinex image processing: Improved fidelity to direct visual observation. Color Imaging Conf. 1996, 36–41. [ Google Scholar]

Hurle RA, Davies G, Parr C, Mason MD, Jenkins SA, Kynaston HG, Jiang WG (October 2005). "Hepatocyte growth factor/scatter factor and prostate cancer: a review". Histology and Histopathology. 20 (4): 1339–49. doi: 10.14670/HH-20.1339. PMID 16136515. Exogenous HGF administered by intravenous injection is cleared rapidly from circulation by the liver, with a half-life of approximately 4 minutes. [26] [27] [28] [29] Modulators [ edit ] Human HGF plasmid DNA therapy of cardiomyocytes is being examined as a potential treatment for coronary artery disease as well as treatment for the damage that occurs to the heart after myocardial infarction. [10] [11] Rychli K, Richter B, Hohensinner PJ, Kariem Mahdy A, Neuhold S, Zorn G, Berger R, Mörtl D, Huber K, Pacher R, Wojta J, Niessner A, Hülsmann M (July 2011). "Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure". Heart. 97 (14): 1158–63. doi: 10.1136/hrt.2010.220228. PMID 21572126. S2CID 22426278. Data and estimates are also shared with the Cabinet Office (CO) as well as other government departments. This is to provide indicators to inform policy, and to evaluate existing policies and their effectiveness at driving social and behavioural change. Strengths and limitationsThis section provides a range of information that describes the quality and characteristics of the survey. Relevance Timeliness refers to the lapse of time between data collection and data delivery. Punctuality refers to the gap between planned and actual data delivery dates.) a b Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA (February 1991). "Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product". Science. 251 (4995): 802–4. Bibcode: 1991Sci...251..802B. doi: 10.1126/science.1846706. PMID 1846706. Ling, Z.G.; Fan, G.L.; Gong, J.W.; Wang, Y.; Lu, X. Perception oriented transmission estimation for high quality image dehazing. Neurocomputing 2017, 224, 82–95. [ Google Scholar] [ CrossRef] Rahman, Z.; Jobson, D.J.; Woodell, G.A. Multi-scale retinex for color image enhancement. IEEE Trans. Image Process. 1996, 6, 1003–1006. [ Google Scholar]